The primary aim of therapy in the patient with hepatitis C is to achieve a sustained virologic response, which is defined as undetectable HCV RNA 6 months after termination of antiviral therapy. Secondary goals of antiviral therapy include improvement in histology and quality of life, and the prevention of HCC.
Patients with persistently abnormal liver enzymes, detectable HCV RNA, and an abnormal liver biopsy are candidates for antiviral therapy.
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